Intranasal Therapy has been an accepted form of treatment in the Ayurvedic system of Indian Medicine. The interest in intranasal delivery of drugs as a non-invasive is increased.Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. Besides this, intranasal route has also been successfully exploited for bypassing the blood brain barrier and subsequently delivering drug molecules to central nervous system. The present article highlights the advantages, barriers, physicochemical factors and formulation related parameters affecting the nasal drug delivery. Also, the applications of nasal route for delivery of peptides and proteins, non-peptide drugs, vaccines and drug molecules to CNS have been summarized in depth.
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